中国神经再生研究(英文版) ›› 2017, Vol. 12 ›› Issue (12): 2100-2105.doi: 10.4103/1673-5374.221170

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

肌肉内脂肪组织(IMAT)和肌内脂肪组织(IntraMAT)通过磁共振成像定量

  

  • 收稿日期:2017-12-02 出版日期:2017-12-15 发布日期:2017-12-15

 Quantification of intermuscular and intramuscular adipose tissue using magnetic resonance imaging after neurodegenerative disorders

Madoka Ogawa1, 2, Robert Lester3, Hiroshi Akima1, 4, Ashraf S. Gorgey3, 5   

  1. 1 Graduate School of Education & Human Development, Nagoya University, Nagoya, Japan
    2 Japan Society for Promotion of Science, Tokyo, Japan
    3 Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VAMC, Richmond, VA, USA
    4 Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan
    5 Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA
  • Received:2017-12-02 Online:2017-12-15 Published:2017-12-15
  • Contact: Ashraf S. Gorgey, M.P.T, Ph.D.,FACSM, ashraf.gorgey@va.gov.
  • Supported by:

    This study was supported in part by Grant-in-Aid for JSPS Research Fellow

摘要:

orcid:0000-0002-9157-6034(Ashraf S. Gorgey)

Abstract:

Ectopic adiposity has gained considerable attention because of its tight association with metabolic and cardiovascular health in persons with spinal cord injury (SCI). Ectopic adiposity is characterized by the storage of adipose tissue in non-subcutaneous sites. Magnetic resonance imaging (MRI) has proven to be an effective tool in quantifying ectopic adiposity and provides the opportunity to measure different adipose depots including intermuscular adipose tissue (IMAT) and intramuscular adipose tissue (IntraMAT) or intramuscular fat (IMF). It is highly important to distinguish and clearly define these compartments, because controversy still exists on how to accurately quantify these adipose depots. Investigators have relied on separating muscle from fat pixels based on their characteristic signal intensities. A common technique is plotting a threshold histogram that clearly separates between muscle and fat peaks. The cut-offs to separate between muscle and fat peaks are still not clearly defined and different cut-offs have been identified. This review will outline and compare the Midpoint and Otsu techniques, two methods used to determine the threshold between muscle and fat pixels on T1 weighted MRI. The process of water/fat segmentation using the Dixon method will also be outlined. We are hopeful that this review will trigger more research towards accurately quantifying ectopic adiposity due to its high relevance to cardiometabolic health after SCI.

Key words: intermuscular adipose tissue, intramuscular adipose tissue, intramuscular fat, ectopic adiposity, magnetic resonance imaging