中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (2): 194-197.doi: 10.4103/1673-5374.226382

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

线粒体移植策略作为中枢神经系统疾病的潜在治疗方法

  

  • 收稿日期:2017-12-07 出版日期:2018-02-15 发布日期:2018-02-15

Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

Jenna L. Gollihue1, 2, Samir P. Patel1, 2, Alexander G. Rabchevsky1, 2   

  1. 1 Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA
    2 Department of Physiology, University of Kentucky, Lexington, KY, USA
  • Received:2017-12-07 Online:2018-02-15 Published:2018-02-15
  • Contact: Alexander G. Rabchevsky,Ph.D., agrab@uky.edu.
  • Supported by:

    This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220.

摘要:

orcid:0000-0002-1991-0915(Alexander G. Rabchevsky)

Abstract:

Mitochondria are essential cellular organelles critical for generating adenosine triphosphate (ATP) for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of “mitochondrial medicine” is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased ATP production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system (CNS) tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.

Key words: oxygen consumption, bioenergetics, oxidative phosphorylation, cellular uptake, replacement strategies, spinal cord injury, mitochondria