中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (2): 237-238.doi: 10.4103/1673-5374.226387

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

血清素在神经系统再生中的作用:再生动物模型的经验教训

  

  • 收稿日期:2018-01-03 出版日期:2018-02-15 发布日期:2018-02-15

Serotonin controls axon and neuronal regeneration in the nervous system: lessons from regenerating animalmodels

Daniel Sobrido-Cameán, María Celina Rodicio, Antón Barreiro-Iglesias   

  1. Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
  • Received:2018-01-03 Online:2018-02-15 Published:2018-02-15
  • Contact: Antón Barreiro-Iglesias, Ph.D.,anton.barreiro@usc.es.
  • Supported by:

    This work was supported by grants from the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund 2007-2013 (BFU2014-56300-P) and the Xunta de Galicia (GPC2014/030). ABI was supported by a grant from the Xunta de Galicia(2016-PG008) and a grant from the crowdfunding platform Precipita(FECYT; Spanish Ministry of Economy and Competitiveness; grant number 2017-CP081).

摘要:

orcid: 0000-0002-7507-080X (Antón Barreiro-Iglesias)

Abstract:

Traumatic brain injury (TBI) is a mechanical injury to brain tissue that leads to an impairment of function and a broad spectrum of symptoms and disabilities; often, it is followed by diffuse axonal injury, which causes denaturation of the white matter and axon retraction, leaving patients with severe brain damage or even in a persistent vegetative state. Spinal cord injury (SCI) is defined as a lesion within the spinal cord that results in the disruption of nerve fibre bundles that convey ascending sensory and descending motor information. In mammals, including humans, SCI can lead to permanent disability and an irreversible loss of function below the site of injury due to the disruption of motor, sensory and autonomic systems. The inability of axons to regrow within the injured central nervous system (CNS) of adult mammals is a fundamental feature that explains the poor regenerative capacity observed after TBI or SCI. In addition, TBI and SCI cause a loss of cells (neurons and glia)due to the primary physical injury. Also, after the primary injury, a cascade of secondary injury events expands the zona of neural tissue injury causing further cell death.