中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (2): 230-231.doi: 10.4103/1673-5374.226393

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

周围神经再生的领土最大化假设

  

  • 收稿日期:2017-04-18 出版日期:2018-02-15 发布日期:2018-02-15

Territory maximization hypothesis during peripheral nerve regeneration

 Jiu-xu Deng, Jian Weng, Yu-hui Kou, Pei-xun Zhang, Yan-hua Wang, Na Han, Bao-guo Jiang, Xiao-feng Yin   

  1. Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing, China
  • Received:2017-04-18 Online:2018-02-15 Published:2018-02-15
  • Contact: Bao-guo Jiang or Xiao-feng Yin,xiaofengyin@bjmu.edu.cn.
  • Supported by:

    This study was supported by grants from the National Program on Key Basic Rtesearch Project of China (973 Program), No.2014CB542200; the National Natural Science Foundation of China,No. 31471144, 31571002, 31271284, 31171150, 81171146,30971526; a grant from Program for Innovative Research Team in University of Ministry of Education of China, No. IRT1201.

摘要:

orcid: 0000-0001-9932-642X (Xiao-feng Yin)
          0000-0003-2670-3153 (Jiu-xu Deng)

Abstract:

Territory awareness refers to the notion that an organism lives in a territory, considers this territory its own, and prevents entry of other organisms. Generally, an organism maximizes its territory for best survival advantages, which subsequently allows for species continuation. Axonal sprouting occurs when peripheral nerves regenerate. The distal regenerated nerve fibers significantly outnumber those at the proximal end of the donor nerve, which has long been termed the “multiple amplification”phenomenon (Yin et al., 2013). Previous studies have shown that sprouting and multiple amplification occur during peripheral nerve regeneration. The regenerated nerve fibers greatly outnumber the original fibers of the donor nerve, thereby filling the entire physiological space of the acceptor nerves and allowing for the peripheral neurons to maximize innervation to the target organs. However, the role of the fibers in the amplification processes remains to be shown, as well as the factors involved in amplification. Additionally, very little is understood about how the fibers serve as donor nerves to repair peripheral nerve injury, whether there is a biological motive for the regeneration process, and whether the peripheral neurons have their own behavioral pattern. Further investigation might offer different perspectives about peripheral nerve regeneration and the potential application in disease treatments.