中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (3): 413-414.doi: 10.4103/1673-5374.228717

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

靶向微血栓和泊洛沙姆神经炎症治疗脑外伤后神经保护作用

  

  • 收稿日期:2018-02-14 出版日期:2018-03-15 发布日期:2018-03-15

Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury

Ye Xiong1, Li Zhang2, Zheng Gang Zhang2, Asim Mahmood1, Michael Chopp2, 3   

  1. 1 Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA
    2 Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    3Department of Physics, Oakland University, Rochester, MI, USA
  • Received:2018-02-14 Online:2018-03-15 Published:2018-03-15
  • Contact: Ye Xiong, M.D., Ph.D., yxiong1@hfhs.org.

摘要:

orcid:0000-0001-9770-6031 (Ye Xiong)

Abstract:

Traumatic brain injury (TBI): Despite improved supportive and rehabilitative care of TBI patients, TBI remains a leading cause of death and disability worldwide. To date, no effective pharmacological treatments are available for TBI. The mechanisms underlying brain damage and repair following TBI are complex and not completely understood. Coagulopathy after TBI is frequent and an independent prognostic factor for unfavorable outcome and prognosis (Stein and Smith, 2004). It may be amenable to treatment,and effective management of coagulopathy may protect from secondary injury and poor outcomes. Although the main challenge for TBI management is to address the risk of hypocoagulopathy with prolonged bleeding and progression of hemorrhagic lesions, the risk of hypercoagulopathy with an increased microthrombosis formation warrants investigation to reduce neurological deficits after TBI.