中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (3): 567-568.doi: 10.4103/1673-5374.228764

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  • 收稿日期:2017-12-05 出版日期:2018-03-15 发布日期:2018-03-15

The biological clock: future of neurological disorders therapy

Sagar Gaikwad   

  1. Institute of Life Sciences, NALCO Square, Bhubaneswar, India
  • Received:2017-12-05 Online:2018-03-15 Published:2018-03-15
  • Contact: Sagar Gaikwad, Ph.D., sagar.g@ils.res.in or sagargaikwad2011@gmail.com
  • Supported by:

    The study was financially supported by DST-SERB (PDF/2016/001369). The Author acknowledges Dr. Birendra Prusty, Dr. A. Raj Kumar Patro and Dr.Diwakar Singh for helpful discussion.

摘要:

orcid: 0000-0003-0240-1357 (Sagar Gaikwad)

Abstract:

The seminal, discoveries by Jeffrey Connor Hall, Michael Rosbash and Michael Warren Young have earned the Nobel Prize in Physiology and Medicine 2017 for revealing a crucial physiological mechanism explaining biological clock, with important implications for human health and diseases. The work explains the interplay between the biological clock, the transcriptional feedback loop, and neuroscience, where they identified genes and proteins that work together both in humans and other animals.This article describes the link between biological clock disruption and consequent neurodegeneration and also highlights the significance of biological clock modulators for possible clinical interventions in neurological disorders.