中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (4): 639-640.doi: 10.4103/1673-5374.230285

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

切断造成神经胶质细胞损伤从横切部位被移除

  

  • 收稿日期:2018-03-14 出版日期:2018-04-15 发布日期:2018-04-15

Axotomy induces damage to glial cells remote from the transection site in the peripheral nervous system

Anatoly B. Uzdensky   

  1. Laboratory of Molecular Neurobiology, Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia
  • Received:2018-03-14 Online:2018-04-15 Published:2018-04-15
  • Contact: Anatoly B. Uzdensky, Professor,auzd@yandex.ru
  • Supported by:

    Supported by the Ministry of Education and Science of Russia grants 6.4951.2017/6.7 and 6.6З24.2017/8.9.

摘要:

orcid: 0000-0002-0344-434X (Anatoly B. Uzdensky)

Abstract:

Traumatic cerebral or spinal cord injury induced by military, traffic,and sports accidents, falls or environmental and anthropogenic catastrophes are among main causes of people mortality and disability,especially in young and middle age men (Kobeissy, 2015). Axon transection, or axotomy, occurs in wounds and during surgery. Central neurons do not regenerate and die, but in the peripheral nervous system 25–30% of axotomized motor or sensory neurons survive and can regenerate and restore lost connections to their target cells. In order to treat the consequences of nerve injury, the balance between neurodegeneration and neuroprotection processes should be rapidly shifted to neuron survival. Unfortunately, reliable neuroprotective medications with proven efficiency are not found yet. So, comprehensive and deep study of molecular processes that occur after axon transection is required.