中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (5): 779-785.doi: 10.4103/1673-5374.232460

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

基于三维静电分子相互作用的轴突、树突和体细胞的信号传导

  

  • 收稿日期:2018-03-19 出版日期:2018-05-15 发布日期:2018-05-15

Nerve conduction models in myelinated and unmyelinated nerves based on three-dimensional electrostatic interaction

Tetsuya Akaishi1, 2   

  1. 1 Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
    2 Department of Neurology, Yonezawa National Hospital, Yonezawa, Japan
  • Received:2018-03-19 Online:2018-05-15 Published:2018-05-15
  • Contact: Tetsuya Akaishi, M.D., Ph.D.,t-akaishi@med.tohoku.ac.jp.

摘要:

orcid:0000-0001-6728-4966(Tetsuya Akaishi)

Abstract:

Until now, nerve conduction has been described on the basis of equivalent circuit model and cable theory, both of which supposed closed electric circuits spreading inside and outside the axoplasm. With these conventional models, we can simulate the propagating pattern of action potential along the axonal membrane based on Ohm’s law and Kirchhoff’s law. However, we could not fully explain the different conductive patterns in unmyelinated and myelinated nerves with these theories. Also, whether we can really suppose closed electrical circuits in the actual site of the nerves or not has not been fully discussed yet. In this report, a recently introduced new theoretical model of nerve conduction based on electrostatic molecular interactions within the axoplasm will be reviewed. With this new approach, we can explain the different conductive patterns in unmyelinated and myelinated nerves. This new mathematical conductive model based on electrostatic compressional wave in the intracellular fluid may also be able to explain the signal integration in the neuronal cell body and the back-propagation mechanism from the axons to the dendrites. With this new mathematical nerve conduction model based on electrostatic molecular interactions within the intracellular fluid, we may be able to achieve an integrated explanation for the physiological phenomena taking place in the nervous system.

Key words: nerve conduction, ion channels, electrostatic interactions, electrostatic compressional wave, saltatory conduction, myelinated nerves, unmyelinated nerves, saltatory equations