中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (6): 955-961.doi: 10.4103/1673-5374.233432

• 综述:退行性病与再生 • 上一篇    下一篇

天然多酚对阿尔茨海默病和帕金森氏症朊病毒样蛋白质聚集体的影响

  

  • 收稿日期:2018-04-17 出版日期:2018-06-15 发布日期:2018-06-15

Natural polyphenols effects on protein aggregates in Alzheimer’s and Parkinson’s prion-like diseases

Aline Freyssin, Guylène Page, Bernard Fauconneau, Agnès Rioux Bilan   

  1. University of Poitiers, EA3808 NEUVACOD (Neurovascular Unit and Cognitive Disorders), Pôle Biologie Santé, Poitiers, France
  • Received:2018-04-17 Online:2018-06-15 Published:2018-06-15
  • Contact: Agnès Rioux Bilan, Ph.D.,agnes.rioux-bilan@univ-poitiers.fr.

摘要:

orcid:0000-0003-2798-8576(Agnès Rioux Bilan)

Abstract:

Alzheimer’s and Parkinson’s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer’s disease, α-synuclein and synphilin-1 for Parkinson’s disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer’s and Parkinson’s diseases.

Key words: natural polyphenols, protein aggregates, Alzheimer’s disease, amyloid peptide, hyperphosphorylated tau, amyloid plaques, Parkinson’s disease, α-synuclein, synphilin-1