中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (6): 987-988.doi: 10.4103/1673-5374.233440

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

鸡尾酒和包容的时间

  

  • 收稿日期:2018-04-28 出版日期:2018-06-15 发布日期:2018-06-15

A time for cocktails and inclusion

Shenandoah Robinson1, Frances J. Northington2, Lauren L. Jantzie 3   

  1. 1 Division of Pediatric Neurosurgery, Johns Hopkins UniversitySchool of Medicine, Baltimore, MD, USA;
    2 Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;
    3 Departments of Pediatrics and Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA
  • Received:2018-04-28 Online:2018-06-15 Published:2018-06-15
  • Contact: Shenandoah Robinson, M.D.,srobin81@jhmi.edu.

摘要:

orcid: 0000-0001-9388-3495 (Shenandoah Robinson)

Abstract:

Perinatal brain injury (PBI) is one of the most important causes of lifelong deficits in cognition, behavior, social interaction and motor skills, as well as epilepsy. PBI encompasses, but is not limited to, hypoxic-ischemic encephalopathy (HIE), intraventricular hemorrhage, periventricular leukomalacia and encephalopathy of prematurity. PBI affects both preterm and term neonates and is a reflection of diverse and complex etiologies and initiating insults,including prenatal genetic and environmental contributions, sentinel obstetrical and perinatal events, and drug exposures. Additionally, consequences of other illnesses and events such as neonatal sepsis, cardiac defects and infantile traumatic brain injury can result in central nervous system (CNS) damage that contributes to PBI. Thus, a large majority of infants who suffer PBI experience a complex blend of CNS insults that impact multiple molecular, cellular, microstructural and ultrastructural pathophysiological mechanisms and result in cumulative deficits.