中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1125-1135.doi: 10.4103/1673-5374.235012

• 综述:神经损伤修复保护与再生 •    下一篇

缺氧缺血性脑损伤对干细胞动员,迁移,粘附和增殖的影响

  

  • 收稿日期:2018-05-05 出版日期:2018-07-15 发布日期:2018-07-15

The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation

Stephanie M. Parry, Eric S. Peeples   

  1. Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
  • Received:2018-05-05 Online:2018-07-15 Published:2018-07-15
  • Contact: Eric S. Peeples, M.D.,eric.peeples@unmc.edu.

摘要:

orcid:0000-0002-2892-2678(Eric S. Peeples)

Abstract:

Neonatal hypoxic-ischemic encephalopathy continues to be a significant cause of death or neurodevelopmental delays despite standard use of therapeutic hypothermia. The use of stem cell transplantation has recently emerged as a promising supplemental therapy to further improve the outcomes of infants with hypoxic-ischemic encephalopathy. After the injury, the brain releases several chemical mediators, many of which communicate directly with stem cells to encourage mobilization, migration, cell adhesion and differentiation. This manuscript reviews the biomarkers that are released from the injured brain and their interactions with stem cells, providing insight regarding how their upregulation could improve stem cell therapy by maximizing cell delivery to the injured tissue.

Key words: brain-derived neurotrophic, hypoxia inducible, erythropoietin, factor, matrix metalloproteinase, neonatal, stromal cell-derived, vascular endothelial growth