中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1151-1155.doi: 10.4103/1673-5374.235018

• 综述:颅神经损伤修复保护与再生 • 上一篇    下一篇

改善嗅觉神经元再生的因素

  

  • 收稿日期:2018-05-05 出版日期:2018-07-15 发布日期:2018-07-15

Factors that modulate olfactory dysfunction

Kate Beecher1, 2, 3, James A. St John3, 4, Fatemeh Chehrehasa1, 2, 3   

  1. 1 School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland, Australia
    2 Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    3 Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia
    4 Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia
  • Received:2018-05-05 Online:2018-07-15 Published:2018-07-15
  • Contact: Fatemeh Chehrehasa, Ph.D., fatemeh.chehrehasa@qut.edu.au.
  • Supported by:

    This work was supported by a grant from the Perry Cross Spinal Research Foundation to FC, JAST and by Queensland University of Technology to FC.

摘要:

orcid:0000-0002-3702-9179(Fatemeh Chehrehasa)

Abstract:

The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments.

Key words: olfactory, neuron, regeneration, anosmia, loss of smell, degeneration, bulbectomy, ensheathing cells, growth factor, epithelium, receptor