中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1181-1182.doi: 10.4103/1673-5374.235024

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

血管内皮细胞生长因子:运动神经元的基本神经营养因子?

  

  • 收稿日期:2018-05-24 出版日期:2018-07-15 发布日期:2018-07-15

Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?

Paula M. Calvo, Angel M. Pastor, Rosa R. de la Cruz   

  1. Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain
  • Received:2018-05-24 Online:2018-07-15 Published:2018-07-15
  • Contact: Angel M. Pastor, Ph.D., ampastor@us.es.
  • Supported by:

    This work was supported by Ministerio de Economía y Competitividad-FEDER (Grant reference: BFU2015-64515-P) in Spain. PMC was a scholar of MEC (BES-2016-077912) in Spain.

摘要:

orcid: 0000-0002-6213-7454 (Angel M. Pastor)

Abstract:

Vascular endothelial growth factor (VEGF), an angiogenic factor with neuroprotective effects: The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability. VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B, VEGF-C, VEGF-D and placental growth factor . Interestingly, VEGF-B shares a high degree of homology with VEGF but, in contrast to VEGF, has low angiogenic activity and is not pro-inflammatory. VEGF-A binds to two tyrosine quinase receptors,named VEGFR-1 and VEGFR-2, and also to the coreceptor neuropilin-1.By contrast, VEGF-B only binds to the tyrosine kinase receptor VEGFR-1 and also to the coreceptor neuropilin-1.