中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1183-1184.doi: 10.4103/1673-5374.235025

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

骨形态发生蛋白信号:围产期脑损伤中白质保护的有希望的靶标

  

  • 收稿日期:2018-05-22 出版日期:2018-07-15 发布日期:2018-07-15

Bone morphogenetic protein signaling: a promising target for white matter protection in perinatal brain injury

 Jill Chang1, Robert W. Dettman2, Maria L.V. Dizon1   

  1. 1 Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;
    2 Stanley Manne Research Institute, Chicago, IL, USA
  • Received:2018-05-22 Online:2018-07-15 Published:2018-07-15
  • Contact: Maria L.V. Dizon, M.D.,m-dizon@northwestern.edu.

摘要:

orcid: 0000-0002-0102-4157 (Maria L.V. Dizon)

Abstract:

Prematurely born newborns, as well as those born at term, may suffer from several types of brain injury including hypoxic-ischemic injury, intracranial hemorrhage, both intraventricular and parenchymal, and injury that is the consequence of intrauterine growth restriction (IUGR). Injury of all types can impact the motor and cognitive abilities of survivors. The mechanisms leading to disability are not completely understood. Here we discuss the role of the bone morphogenetic protein (BMP) signaling pathway in newborn brain injury. We review the evidence that the BMP signaling pathway is activated in various injury types and discuss the downstream effects of its activation and possible interventions to curtail the effects of this pathway’s activation. In addition, we identify interactions with other signaling pathways important in neurodevelopment.