中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1185-1186.doi: 10.4103/1673-5374.235026

• 观点:退行性病与再生 • 上一篇    下一篇

神经退行性疾病是基质分解的一个功能:如何重建细胞外基质和细胞内基质

  

  • 收稿日期:2018-05-09 出版日期:2018-07-15 发布日期:2018-07-15

Neurodegenerative diseases are a function of matrix breakdown: how to rebuild extracellular matrix and intracellular matrix

Greg Maguire   

  1. BioRegenerative Sciences, Inc., NeoGenesis, Inc., San Diego, CA, USA
  • Received:2018-05-09 Online:2018-07-15 Published:2018-07-15
  • Contact: Greg Maguire, Ph.D., gregmaguire5@gmail.com

摘要:

orcid: 0000-0001-5484-6157 (Greg Maguire)

Abstract:

Matrix within cells, the cytoskeleton, and that which surrounds cells,the extracellular matrix (ECM), are connected to one another through a number of receptors including those in primary cilia, serving as an important chemical and physical signaling system: Mechanical forces generated through the matrix play a critical role in determining the form and function of tissues. Such forces, even in adult tissues, will be important given that breakdown of the ECM in adults may lead to the tissue changing from an adult phenotype to one of primordial or embryonic. As an example, chemical and mechanical signaling from the microenvironment and ECM to the cell can be so powerful as to change cellular phenotype from one of cancer to a normal somatic form. Even in development and inheritance, the matrix is important for what embryos receive from egg and sperm upon fertilization. Centrioles, the matrix structures responsible for cell division, are given by the paternal gamete. In the oocytes, the maternal gametes, the centriole is lost through desolvation.Thus, paternal matrix inheritance through the centriole structure is another important example of mechanism of heredity beyond the genome that may have consequences to neural dysfunction.