中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1187-1188.doi: 10.4103/1673-5374.235027

• 观点:退行性病与再生 • 上一篇    下一篇

脑部修复帕金森病:矩阵中的答案是?

  

  • 收稿日期:2018-05-04 出版日期:2018-07-15 发布日期:2018-07-15

Brain repair for Parkinson’s disease:is the answer in the matrix?

Niamh Moriarty, Eilís Dowd   

  1. Pharmacology & Therapeutics and Galway Neuroscience Centre, National University of Ireland, Galway, Ireland
  • Received:2018-05-04 Online:2018-07-15 Published:2018-07-15
  • Contact: Eilís Dowd, BSc, Ph.D., eilis.dowd@nuigalway.ie.
  • Supported by:

    Our research in this field is supported by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2015) under the Marie Sklodowska-Curie Innovative Training Networks and Grant Agreement No. 676408, Science Foundation Ireland (11/RFP/NES/3183),and through a postgraduate scholarship from the Irish Research Council to Niamh Moriarty.

摘要:

orcid: 0000-0002-2668-539X (Eilís Dowd)

Abstract:

Two hundred years after James Parkinson first described the cardinal motor symptoms of the disorder that would later bear his name, there is still an irrefutable need for a therapy that targets the underlying pathophysiology of the disease and not solely its symptoms. Parkinson’s disease (PD) is classically characterised by Lewy body formation and a relatively selective degeneration of nigrostriatal dopaminergic neurons. The loss of dopaminergic neurons from the substantia nigra pars compacta causes a consequential depletion of the neurotransmitter dopamine from the striatum, and it is this loss that causes the motor symptoms experienced by patients.To date, all treatments for this condition are symptomatic in that they simply endeavour to correct the neurochemical and/or electrical anomalies caused by striatal dopaminergic deafferentation in an attempt to improve motor function. While such symptomatic approaches show extraordinary efficacy in the early years after initiating treatment, the underlying disease pathology continues to progress, and eventually their efficacy subsides. In view of this, there remains an urgent need for an alternative treatment approach that is capable of protecting or repairing the brain in order to provide a more sustained benefit to patients.