中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (7): 1193-1194.doi: 10.4103/1673-5374.235030

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

内源性Nogo受体拮抗剂外侧嗅束引导物质蛋白可将非允许性环境转换为宽松的大脑环境可用于轴突再生

  

  • 收稿日期:2018-05-03 出版日期:2018-07-15 发布日期:2018-07-15

Lateral olfactory tract usher substance (LOTUS) protein, an endogenous Nogo receptor antagonist, converts a non-permissive to permissive brain environment for axonal regrowth

Tomoko Hirokawa, Kohtaro Takei   

  1. Molecular Medical Bioscience Laboratory, Yokohama City University Graduate School of Medical Life Science, Yokohama, Japan
  • Received:2018-05-03 Online:2018-07-15 Published:2018-07-15
  • Contact: Kohtaro Takei, Ph.D.,kohtaro@yokohama-cu.ac.jp.
  • Supported by:

    This work was supported by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by grants for Research and Development project of Yokohama City University.

摘要:

orcid: 0000-0001-6938-0812 (Kohtaro Takei)

Abstract:

It is well known that primates, including humans, hardly recover motor function after spinal cord injury (SCI) when compared with non-primate mammals such as rodents. This limited functional recovery is in part due to a non-permissive environment of the central nervous system (CNS) inhibiting axonal regrowth. This inhibitory environment for axonal regrowth is mainly caused by interaction of axon growth inhibitors with their common receptor, Nogo receptor-1 (NgR1). Axon regrowth inhibitors such as Nogo proteins, myelin associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and B lymphocyte stimulator (BLyS) are derived from glial cells in damaged brain.