中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (8): 1342-1345.doi: 10.4103/1673-5374.235220

• 综述:退行性病与再生 • 上一篇    下一篇

目前帕金森病的手术治疗和潜在的治疗目标

  

  • 收稿日期:2018-06-02 出版日期:2018-08-15 发布日期:2018-08-15

Current surgical treatments for Parkinson’s disease and potential therapeutic targets

Darrin J. Lee, Robert F. Dallapiazza, Philippe De Vloo, Andres M. Lozano   

  1. Division of Neurosurgery, Toronto Western Hospital, Department of Surgery, University of Toronto, Toronto, Canada
  • Received:2018-06-02 Online:2018-08-15 Published:2018-08-15
  • Contact: Darrin J. Lee, M.D., Ph.D., darrin.lee@uhnresearch.ca.

摘要:

orcid:0000-0002-0798-8731(Darrin J. Lee)

Abstract:

Currently, the most common surgical treatment for Parkinson’s disease is deep brain stimulation (DBS). This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. In addition to DBS, ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. In this review, we discuss evolving surgical techniques, targets, and emerging technology. In addition, we evaluate potential paradigm shifts in treatment, including gene therapy, immunotherapy and cell transplantation. While these new techniques and treatment options are still in their infancy, advances in Parkinson’s disease treatment are rapidly expanding.

Key words: Parkinson’s disease, deep brain stimulation, pallidotomy, thalamotomy, focused ultrasound, gene therapy, immunotherapy, cell transplantation