中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1534-1537.doi: 10.4103/1673-5374.235221

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

许旺细胞中Myc相互作用锌指蛋白1不含POZ蛋白域:周围神经病的表观遗传学意义

  

  • 收稿日期:2018-04-28 出版日期:2018-09-15 发布日期:2018-09-15

Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy

David Fuhrmann, Hans-Peter Elsässer   

  1. Department of Cytobiology and Cytopathobiology, Philipps University of Marburg, Marburg, Germany
  • Received:2018-04-28 Online:2018-09-15 Published:2018-09-15
  • Contact: Hans-Peter Elsasser, Ph.D., elsaesse@mailer.uni-marburg.de.
  • Supported by:

     This work was supported by Deutsche Forschungsgemeinschaft (DFG grant EL125/6-1)

摘要:

orcid:0000-0003-1377-6521(Hans-Peter Elsässer)

Abstract:

Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during postnatal development, as well as fine-tuned re- and transdifferentiation in response to peripheral nerve injury. Epigenetic histone modifications play a major role during the differentiation of embryonic stem cells and diverse organ specific progenitor cells, yet only little is known about the epigenetic regulation of Schwann cells. Just recently, Fuhrmann et al. reported how the transcription factor Myc-interacting zinc-finger protein 1 (Miz1) might contribute to Schwann cell differentiation through repression of the histone demethylase Kdm8. Here, we discuss the potential novel role of Miz1 in Schwann cell differentiation and give a short overview about previously reported histone modifications underlying peripheral nerve development and response to injury.

Key words: Schwann cell, differentiation, peripheral nerve injury, histone methylation, epigenetics, Miz1