中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1516-1519.doi: 10.4103/1673-5374.237110

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

低强度原爆炸波作用下的纳米超微结构脑损伤

  

  • 收稿日期:2018-06-08 出版日期:2018-09-15 发布日期:2018-09-15

Nanometer ultrastructural brain damage following low intensity primary blast wave exposure

Hailong Song1, Landry M. Konan1, Jiankun Cui1, 4, Catherine E. Johnson2, Graham K. Hubler1, Ralph G. DePalma3, Zezong Gu1, 4   

  1. 1 Department of Pathology & Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO, USA
    2 Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Rolla, MO, USA
    3 Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA
    4 Truman VA Hospital Research Service, Columbia, MO, USA
  • Received:2018-06-08 Online:2018-09-15 Published:2018-09-15
  • Contact: Zezong Gu, Ph.D.,guze@health.missouri.edu
  • Supported by:

    This publication was made possible by funding from the DoD Congressionally Directed Medical Research Programs (CDMRP) for the Peer Reviewed Alzheimer’s Research Program Convergence Science Research Award (PRARP-CSRA; AZ140109) and the research funds of the University of Missouri (to ZG).

摘要:

orcid:0000-0002-2411-7460(Zezong Gu)

Abstract:

Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast mediated pathophysiology upon later neurobehavioral disorders has been controversial. Developing a military preclinical blast model to simulate the pathophysiology of human blast injury is an important first step. This article provides an overview of primary blast effects and perspectives of our recent studies demonstrating ultrastructural changes in the brain and behavioral disorders resulting from open-field blast exposures up to 46.6 kPa using a murine model. The model is scalable and permits exposure to varying magnitudes of primary blast injuries by placing animals at different distances from the blast center or by changing the amount of C4 charge. We here review the implications and future applications and directions of using this animal model to uncover the underlying mechanisms related to primary blast injury. Overall, these studies offer the prospect of enhanced understanding of the pathogenesis of primary low-intensity blast-induced TBI and insights for prevention, diagnosis and treatment of blast induced TBI, particularly mTBI/concussion related to current combat exposures.

Key words: mild traumatic brain injury, open-field blast, primary blast wave, blast physics, animal model, ultrastructural abnormalities, behavior