中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1524-1529.doi: 10.4103/1673-5374.237112

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

外伤性脊髓损伤后白细胞基因表达的改变:临床意义

  

  • 收稿日期:2018-06-08 出版日期:2018-09-15 发布日期:2018-09-15

Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications

Paige E. Herman1, Ona Bloom1, 2   

  1. 1 The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA
    2 Departments of Physical Medicine and Rehabilitation, Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Manhasset, NY, USA
  • Received:2018-06-08 Online:2018-09-15 Published:2018-09-15
  • Contact: Ona Bloom, Ph.D., obloom@northwell.edu
  • Supported by:

    This research was supported by grants from the Craig H. Neilsen Foundation, the NY State Empire Clinical Research Program, and the NY State Spinal Cord Injury Research Board (grants to OB).

摘要:

orcid:0000-0002-8340-2392(Ona Bloom)

Abstract:

In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardiovascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to improve immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.

Key words: traumatic spinal cord injury, inflammation, immune cells, functional genomics, gene expression, autoimmunity, microarray, chronic spinal cord injury