中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1546-1547.doi: 10.4103/1673-5374.237114

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

脑脊液和神经干细胞生长抑制剂

  

  • 收稿日期:2018-06-08 出版日期:2018-09-15 发布日期:2018-09-15

Cerebrospinal fluid and neural stem cell niche control

Mª Isabel Alonso1, 2, Angel Gato1, 2   

  1. 1 Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain;
    2 Laboratorio de Desarrollo y Teratología del Sistema Nervioso, Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Valladolid, Valladolid, Spain
  • Received:2018-06-08 Online:2018-09-15 Published:2018-09-15
  • Contact: Angel Gato, M.D., gato@med.uva.es.

摘要:

orcid: 0000-0002-3936-099X (Angel Gato)

Abstract:

Neurogenesis from inner brain neural stem cells (NSCs) is a process which takes place continuously in mammals throughout their life. However, the main ontogenic difference is the intensity of neurogenesis, which commences as a very intensive and global activity in the early embryonic brain (neural tube), persists in fetal and newborn stages, and declines significantly in adulthood, becoming restricted to specific places with low neurogenic activity such as the subventricular zone (SVZ) and the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus.