中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1550-1551.doi: 10.4103/1673-5374.237116

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

自由基清除剂依达拉奉和少突胶质细胞保护/再生

  

  • 收稿日期:2018-06-23 出版日期:2018-09-15 发布日期:2018-09-15

A radical scavenger edaravone and oligodendrocyte protection/regenerati

Hajime Takase, Josephine Lok, Ken Arai   

  1. Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Received:2018-06-23 Online:2018-09-15 Published:2018-09-15
  • Contact: Ken Arai, Ph.D., karai@partners.org.
  • Supported by:

    Supported in part by National Institutes of Health and the Rotary Foundation Global Scholarship Grants (GG1759314).

摘要:

orcid: 0000-0003-1615-3258 (Ken Arai)

Abstract:

Cerebral white matter is vulnerable to oxidative stress: Oxidative stress is one of the major harmful conditions for the central nervous system (CNS). Oxidative stress is a state from an imbalance between free radical production and their removal by antioxidants,resulting in an excessive amount of reactive oxygen species (ROS) in cells and tissues. ROS causes cell damage due to oxidation of cellular components, including DNAs, proteins, and lipids. During physiological conditions, small amounts of ROS are generated in the process of normal biological activity, and ROS at physiological levels play important roles in maintaining cellular homeostasis. However, during pathological conditions, ROS levels are increased and excessive ROS can lead to deleterious effects on many kinds of cells.