中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1542-1543.doi: 10.4103/1673-5374.237117

• 观点:退行性病与再生 • 上一篇    下一篇

PARK7的新兴表观遗传学及其在神经退行性疾病中的意义

  

  • 收稿日期:2018-03-31 出版日期:2018-09-15 发布日期:2018-09-15

The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

George D. Vavougios1, Sotirios G. Zarogiannis2   

  1. 1 Department of Neurology, Athens Naval Hospital, Athens, Greece;
    2 Department of Physiology, Faculty of Medicine, University of Thessaly, Larissa, Greece
  • Received:2018-03-31 Online:2018-09-15 Published:2018-09-15
  • Contact: George D. Vavougios, M.D., Ph.D.,dantevavougios@hotmail.com.

摘要:

orcid: 0000-0002-0413-4028 (George D. Vavougios)

Abstract:

PARK7/DJ-1 is a multifunctional protein that acts as a regulator in stress responsive cascades. Since its original discovery as a novel oncogene, DJ-1 was further implicated in the correspondingly dubbed PARK7 autosomal recessive early onset Parkinson’s Disease variant, expanding the spectrum of its pathophysiology to neurodegenerative disease. DJ-1’s physiological roles have correspondingly expanded in the literature, effectively revealing an almost ubiquitous presence in cellular compartments and tissues.DJ-1’s functions mediate a diverse armamentarium of cytoprotective effects such as RNA binding, SUMOylation, androgen receptor binding, and regulation of mitochondrial dynamics as well as a recently discovered deglycase activity.