中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (9): 1619-1621.doi: 10.4103/1673-5374.237125

• 原著:退行性病与再生 • 上一篇    下一篇

意大利卡拉布里亚地区痴呆症神经精神症状疼痛评估和止痛药使用准确性的证据

  

  • 收稿日期:2018-06-26 出版日期:2018-09-15 发布日期:2018-09-15

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region, Italy

Damiana Scuteri1, Maria Roberta Garreffa2, Stefania Esposito2, Giacinto Bagetta1, Maria Diana Naturale3, Maria Tiziana Corasaniti3   

  1. 1 Preclinical and Translational Pharmacology, Department of Pharmacy Health Science and Nutrition, University of Calabria, Rende, Italy
    2 Pharmacy Unit, “Mater Domini” University Hospital, Catanzaro, Italy
    3 Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, Italy
  • Received:2018-06-26 Online:2018-09-15 Published:2018-09-15
  • Contact: Giacinto Bagetta, Professor,g.bagetta@unical.it.

摘要:

orcid:0000-0001-8540-6218(Giacinto Bagetta)

Abstract:

During the clinical course of dementia, beside cognitive impairment and memory loss, a very complex challenge is posed by the neuropsychiatric symptoms (NPSs). Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 years. To gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro (Italy). The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with nonsteroidal antinflammatory drugs, opioids, and anticonvulsants have been monitored. The latter have been evaluated statistically for difference between the treatment before (pre) and after (post) the settlement of acetylcholinesterase inhibitors (AChEI) or memantine therapy. The results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria (Italy).

Key words: Alzheimer’s disease, dementia, neuropsychiatric symptoms, pain, appropriate prescriptions, aromatherapy, opioids, α2δ-1 ligands