中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (10): 1685-1692.doi: 10.4103/1673-5374.238603

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

褪黑激素用于治疗脊髓损伤

  

  • 收稿日期:2018-05-09 出版日期:2018-10-15 发布日期:2018-10-15

Melatonin for the treatment of spinal cord injury

Yan Zhang1, Wen-Xiu Zhang1, Yan-Jun Zhang2, Ya-Dong Liu2, Zong-Jian Liu1, Qi-Chao Wu2, Yun Guan1, 3, 4, Xue-Ming Chen1, 2   

  1. 1 Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, China
    2 Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, China
    3 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    4 Department of Neurological Surgery, Johns Hopkins University, Baltimore, MD, USA
  • Received:2018-05-09 Online:2018-10-15 Published:2018-10-15
  • Contact: Yun Guan, MD, PhD or Xue-Ming Chen, MD,yguan1@jhmi.edu or xuemingchen@sina.com
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81671161 (to ZJL).

摘要:

orcid:0000-0003-1321-6655(Yun Guan)

Abstract:

Spinal cord injury (SCI) from trauma or disease severely impairs sensory and motor function. Neurore­habilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxy­tetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.

Key words: spinal cord injury, melatonin, secondary damage, neuroprotection, antioxidative, antiapoptotic, anti-inflammatory, synergistic effects, neural regeneration