中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (10): 1733-1734.doi: 10.4103/1673-5374.238610

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

神经胶质源神经营养因子作为脊髓损伤后的治疗方法

  

  • 收稿日期:2018-06-23 出版日期:2018-10-15 发布日期:2018-10-15

Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury

Stephen D. Ortmann, Daniel J. Hellenbrand   

  1. Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA
  • Received:2018-06-23 Online:2018-10-15 Published:2018-10-15
  • Contact: Daniel J. Hellenbrand, MS,hellenbrand@neurosurgery.wisc.edu.

摘要:

orcid: 0000-0003-4730-5752 (Daniel J. Hellenbrand)

Abstract:

Spinal cord injury (SCI) is a devastating trauma that currently affects 54 people out of every million, which is approximately 270,000 people in the United States (National Spinal Cord Injury Statistical Center, 2013). The effects of such an injury can cause a loss of both motor and sensory function below the injury site, normally leaving the patient unable to care for themselves entirely and relying on family and friends to provide personal care. Currently there are no definitive cures to a SCI; however, several potential treatments are currently being researched. One potential treatment would be the use of glial cell line-derived neurotrophic factor (GDNF), a growth factor that affects both neurons and astrocytes, which are support cells that protect neurons and maintain homeostasis. This has been shown to decrease lesion size, reduce allodynia, and regenerate axons in the central nervous system (CNS) and peripheral nervous system (PNS).