中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (10): 1741-1742.doi: 10.4103/1673-5374.238612

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

内层视网膜的神经保护:Müller细胞和乳酸盐

  

  • 收稿日期:2018-07-14 出版日期:2018-10-15 发布日期:2018-10-15

Neuroprotection of the inner retina: Müller cells and lactate

Rupali Vohra1, Miriam Kolko1, 2   

  1. 1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark;
    2 Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark
  • Received:2018-07-14 Online:2018-10-15 Published:2018-10-15
  • Contact: Miriam Kolko, MD, PhD,miriamk@sund.ku.dk.

摘要:

orcid: 0000-0001-8697-0734 (Miriam Kolko)

Abstract:

Müller cells: The neglected neighbor: Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the retina. Uniquely, Müller cells cover the complete thickness of the retina, and their roles therefore differ correspondingly to the retinal segment in which they are located. In the inner retina, Müller cells are crucial in taking up toxic molecules, such as excessive glutamate from the synapses between bipolar cells and retinal ganglion cells (RGCs), thereby preventing glutamate-induced excitoxic RGC death. Additionally, Müller cells are crucial in maintaining ion balances and have also been suggested to secrete essential neuroprotective factors as well as to buffer energy sources to the neighboring cells. Despite being over looked for decades Müller cells have now been proven essential in overall retinal maintenance, and increasing attention and acknowledgement has been attributed to their mere presence and function.