中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (11): 1887-1889.doi: 10.4103/1673-5374.238614

• 观点:退行性病与再生 • 上一篇    下一篇

基于内质网应激反应在神经退行性疾病和神经疾病中的作用的潜在治疗干预

  

  • 收稿日期:2018-07-16 出版日期:2018-11-15 发布日期:2018-11-15

Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases

Basant K. Puri1, Gerwyn Morris2   

  1. 1 Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK;
    2 IMPACT Strategic Research Centre, School of Medicine,Deakin University, Geelong, Australia
  • Received:2018-07-16 Online:2018-11-15 Published:2018-11-15
  • Contact: Basant K. Puri, MA, PhD, MB, BChir,MSc, MMath, FRCPsych, FRSB, basant.puri@imperial.ac.uk.

摘要:

orcid: 0000-0001-6101-0139 (Basant K. Puri)

Abstract:

In 1945, Porter et al. published an electon microscopy study of cultured chick fibroblasts in which they observed: ‘a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of “vesicles”’ . This constituted the first published observation of the endoplasmic reticulum (ER) and, while it was not evident at that time, this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.