中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (11): 1890-1892.doi: 10.4103/1673-5374.239437

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

金属蛋白酶组织抑制剂触发神经

  

  • 收稿日期:2018-07-23 出版日期:2018-11-15 发布日期:2018-11-15

Tissue inhibitors of metalloproteases strike a nerve

Veronica I. Shubayev1, 2, Alex Y. Strongin3   

  1. 1 Department of Anesthesiology, University of California, San Diego;
    2 VA San Diego Healthcare System, La Jolla, CA, USA;
    3 Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA
  • Received:2018-07-23 Online:2018-11-15 Published:2018-11-15
  • Contact: Veronica I. Shubayev, MD, vshubayev@ucsd.edu.
  • Supported by:

    Department of Veteran’s Affairs Merit Review Award 5I01BX000638 (to VIS) and National Institutes of Health R01DE022757 (to VIS and AYS) supported this study.

摘要:

orcid: 0000-0003-2598-263X (Veronica I. Shubayev)

Abstract:

Signals of touch, pressure, pain, temperature, position, and vibration are transmitted from the peripheral nervous system (PNS) to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia (DRG) neurons. Sensory information gathering relies on functional integrity of DRG neurons and can be interrupted by PNS injury due to trauma, disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recovery after PNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of PNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.