中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (1): 39-42.doi: 10.4103/1673-5374.243698

• 综述:退行性病与再生 • 上一篇    下一篇

优雅地老龄化:社会参与将锻炼和丰富作为抵抗与年龄相关的认知衰退的关键生活方式因素

  

  • 出版日期:2019-01-15 发布日期:2019-01-15

Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline

Tyler J. Dause 1 , Elizabeth D. Kirby 1, 2, 3   

  1. 1 Department of Psychology, The Ohio State University, Columbus, OH, USA
    2 Department of Neuroscience, The Ohio State University, Columbus, OH, USA
    3 Chronic Brain Injury Program, The Ohio State University, Columbus, OH, USA
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Elizabeth D. Kirby, PhD, Kirby.224@osu.edu.
  • Supported by:

    This work was partially supported by a R00 Pathway to Independence Award from NIH/NINDS (R00NS089938) (to EDK).

摘要:

orcid:0000-0001-9313-3790(Elizabeth D. Kirby)

Abstract:

Cognitive impairment is a consequence of the normal aging process that effects many species, including humans and rodent models. Decline in hippocampal memory function is especially prominent with age and often reduces quality of life. As the aging population expands, the need for interventional strategies to prevent cognitive decline has become more pressing. Fortunately, several major lifestyle factors have proven effective at combating hippocampal aging, the most well-known of which are environmental enrichment and exercise. While the evidence supporting the beneficial nature of these factors is substantial, a less well-understood factor may also contribute to healthy cognitive aging: social engagement. We review the evidence supporting the role of social engagement in preserving hippocampal function in old age. In elderly humans, high levels of social engagement correlate with better hippocampal function, yet there is a dearth of work to indicate a causative role. Existing rodent literature is also limited but has begun to provide causative evidence and establish candidate mechanisms. Summed together, while many unanswered questions remain, it is clear that social engagement is a viable lifestyle factor for preserving cognitive function in old age. Social integration across the lifespan warrants more investigation and more appreciation when designing living circumstances for the elderly.

Key words: aging, age-related cognitive decline, social engagement, hippocampus, cognitive enrichment, exercise, memory, neurogenesis