中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (2): 197-200.doi: 10.4103/1673-5374.244781

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

辅酶Q10治疗青光眼神经保护作用的证据

  

  • 出版日期:2019-02-15 发布日期:2019-02-15

Evidences on neuroprotective properties of coenzyme Q10 in the treatment of glaucom

Alessio Martucci, Carlo Nucci   

  1. Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
  • Online:2019-02-15 Published:2019-02-15
  • Contact: Carlo Nucci, MD, PhD, nucci@med.uniroma2.it.

摘要:

orcid: 0000-0002-9142-3927(Carlo Nucci)
           0000-0002-3725-8211(Alessio Martucci)

Abstract:

Glaucoma, the leading cause of visual impairment and irreversible blindness worldwide, is a multifactorial, progressive optic neuropathy characterized by loss of retinal ganglion cells, alterations of the optic nerve head, and specific visual field defects. Clinical evidence shows that intraocular pressure is the major risk factor of the treatable disease. However, in some patients, glaucoma develops and continues to progress despite normal intraocular pressure values, suggesting that other risk factors are involved in the disease. Consequently, neuroprotective treatments, focused on preventing retinal ganglion cells death by acting on different therapeutic strategies but not focused on intraocular pressure reduction, has therefore become of great interest. In this contest, coenzyme Q10, showing evidences in slowing or reversing pathological changes typical of the disease, has been proposed as a potential neuroprotective agent in glaucoma. In this review, we describe the possible mechanisms of action of coenzyme Q10 and the recent evidence in literature regarding the neuroprotective activity of the molecule.

Key words: glaucoma, neuroprotection, retinal ganglion cells, coenzyme Q10, intraocular pressure, mitochondrion, oral administration, neurodegenerative diseases