中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (2): 262-264.doi: 10.4103/1673-5374.244789

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

来自肌腱蛋白C敲除小鼠的经验教训以及对蛛网膜下腔出血的潜在临床应用

  

  • 出版日期:2019-02-15 发布日期:2019-02-15

Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage

Masato Shiba, Hidenori Suzuki   

  1. Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan
  • Online:2019-02-15 Published:2019-02-15
  • Contact: Hidenori Suzuki, MD, PhD, suzuki02@clin.medic.mie-u.ac.jp.
  • Supported by:

    This work was funded by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science, No.17K10825 (to HS) and 17K16640 (to MS).

摘要:

orcid: 0000-0002-8555-5448 (Hidenori Suzuki)

Abstract:

Subarachnoid hemorrhage by a ruptured cerebral aneurysm remains the most devastating cerebrovascular disorders with high morbidity and mortality, which are mainly caused by early brain injury and delayed cerebral ischemia. Despite many experimental and clinical research efforts, the mechanisms of early brain injury as well as delayed cerebral ischemia remain unclarified. However, recent works have suggested that tenascin-C, which is a special type of secreted extracellular matrix proteins, is promising as a novel therapeutic target against post-subarachnoid hemorrhage early brain injury and delayed cerebral ischemia.