中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (3): 405-412.doi: 10.4103/1673-5374.245951

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

研究脊髓损伤后神经元可塑性的康复策略

  

  • 出版日期:2019-03-15 发布日期:2019-03-15

Rehabilitation following spinal cord injury: how animal models can help our understanding of exercise-induced neuroplasticity

Kristina Loy 1 , Florence M. Bareyre 1, 2   

  1. 1 Institute of Clinical Neuroimmunology, Ludwig-Maximilians Universität München, Munich, Germany
    2 Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
  • Online:2019-03-15 Published:2019-03-15
  • Contact: Florence M. Bareyre, PhD, florence.bareyre@med.uni-muenchen.de.
  • Supported by:

    Work in FMB laboratory is supported by grants from the Deutsche Forschungsgemeinschaft (DFG, SFB870), by the Munich Center for Neurosciences (MCN) and the Wings for Life foundation. FMB is also supported by the Munich Center for Systems Neurology (DFG, SyNergy; EXC 1010).

摘要:

orcid: 0000-0002-0917-1725(Florence Bareyre)

Abstract:

Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last decades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difficult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation.

Key words: remodeling, exercise, wheel running, treadmill, detour circuit, propriospinal neuron, corticospinal tract, raphespinal tract, reticulospinal tract, activity, recovery, central nervous system