中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (4): 566-569.doi: 10.4103/1673-5374.247422

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

Rab蛋白和轴突再生

  

  • 出版日期:2019-04-15 发布日期:2019-04-15

Rabs and axonal regeneration

Cheryl Qian Ying Yong 1 , Bor Luen Tang 1, 2,   

  1. 1 Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore
    2 National University of Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
  • Online:2019-04-15 Published:2019-04-15
  • Contact: Bor Luen Tang, PhD, bchtbl@nus.edu.sg.
  • Supported by:

    The work was supported by the National University of Singapore Graduate School for Integrative Sciences and Engineering (to BLT)

摘要:

orcid: 0000-0002-1925-636X(Bor Luen Tang)

Abstract:

Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed.

Key words: Arf, Rab, Rab27b, axon regeneration, axonal transport, cortical neurons, central nervous system injury, membrane trafficking, Myosin-V