中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (6): 967-968.doi: 10.4103/1673-5374.249219

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

扼杀神话:转基因细胞更有益处

  

  • 出版日期:2019-06-15 发布日期:2019-06-15

Busting the myth: more good than harm in transgenic cells

Piñero G, Setton-Avruj P   

  1. Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas (IQUIFIB). Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Patricia Setton-Avruj, PhD, setton@qb.ffyb.uba.ar.
  • Supported by:

    This work was supported by Universidad de Buenos Aires (UBACYT20020100101017) and CONICET, Ministerio de Ciencia, Tecnología e Innovación Productiva de la República Argentina (PIP 830 and PIP 567).

摘要:

orcid: 0000-0001-8510-9598 (Gonzalo Piñero)
           0000-0002-4094-7712 (Patricia Setton-Avruj)

Abstract:

Peripheral neuropathy constitutes a highly incidental condition and a major public health concern worldwide. This pathology is triggered by peripheral nervous system damage as a consequence of systemic disease or ischemic-traumatic lesion. In the latter case, nerve crush, partial or total transection and stretch injury interrupt nerve conduction and impair sensitivity and motility of the innervated area, which brings about partial or total functional loss in the affected limb and disabling neuropathic pain. For these reasons, digging into the molecular mechanisms underlying peripheral neuropathy becomes essential for the development of successful therapeutic strategies.