中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (5): 771-772.doi: 10.4103/1673-5374.249222

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

纵向磁共振成像在脊髓损伤临床前模型中的应用

  

  • 出版日期:2019-05-15 发布日期:2019-05-15

Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury

Harun Najib Noristani, Florence Evelyne Perrin   

  1. INSERM U1198, University of Montpellier, Montpellier, France
  • Online:2019-05-15 Published:2019-05-15
  • Contact: Harun Najib Noristani, harun.noristani@ibn-lab.com; Florence Evelyne Perrin, PhD, florence.perrin@inserm.fr.

摘要:

orcid: 0000-0001-7742-140X (Harun Najib Noristani)
           0000-0002-7630-0515 (Florence Evelyne Perrin)

Abstract:

Spinal cord injury (SCI) is a distressing event with grave socio/economic consequences to our society. Pathophysiological response following SCI involves blood-spinal cord barrier breakdown, neuroinflammation and formation of a glial scar that altogether govern the feasibility of spontaneous axonal re-growth and limited functional recovery. Great advances in understanding SCI pathophysiology have been achieved using numerous transgenic mouse lines developed in different strains. However, there are inherent strain differences that affect inflammation, gliosis, axon regeneration and ultimately functional recovery after SCI.