中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (6): 977-978.doi: 10.4103/1673-5374.250576

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

交感神经激活可能需要付出代价

  

  • 出版日期:2019-06-15 发布日期:2019-06-15

Sympathetic stimulation with norepinephrine may come at a cost

Lakshini Y Herat, Markus P Schlaich, Vance B Matthews   

  1. Dobney Hypertension Centre, School of Biomedical Science - Royal Perth Hospital Unit, University of Western Australia, Perth, Australia; Dobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit, University of Western Australia, Perth, Australia; Department of Cardiology and Department of Nephrology, Royal Perth Hospital, Perth, Australia
  • Online:2019-06-15 Published:2019-06-15
  • Contact: Vance Matthews, PhD, vance.matthews@uwa.edu.au.

摘要:

orcid: 0000-0001-9804-9344 ( Vance B. Matthews )

Abstract:

Norepinephrine (NE; also known as noradrenaline) is the body’s primary adrenergic neurotransmitter which belongs to the catecholamine family. Norepinephrine has pharmacologic effects on the α1, α2, β1, β2 and β3 adrenoceptors. In the brain, norepinephrine increases arousal and alertness, promotes vigilance, enhances formation and retrieval of memory, and focuses attention. It also increases restlessness and anxiety. In the remainder of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle and increases muscle contraction, reduces blood flow to the gastrointestinal system and its motility and lastly, inhibits voiding of the bladder. This last point is particularly interesting in the context of this perspective piece.