中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (7): 1109-1115.doi: 10.4103/1673-5374.251186

• 综述:周围神经损伤修复保护与再生 •    下一篇

使用带有集成物理治疗剂的神经修复术弥补周围神经的较大间隙

  

  • 出版日期:2019-07-15 发布日期:2019-07-15

Bridging larger gaps in peripheral nerves using neural prosthetics and physical therapeutic agents

Muhammad Sana Ullah Sahar 1 , Matthew Barton 2 , Geoffrey Douglas Tansley 1   

  1. 1 School of Engineering and Built Environment, Griffith University, Gold Coast, Queensland, Australia
    2 Clem Jones Centre for Neurobiology and Stem Cell Therapies, Griffith University, Gold Coast, Queensland, Australia
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Muhammad Sana Ullah Sahar, MS, m.sahar@griffithuni.edu.au

摘要:

orcid: 0000-0001-7140-4502 (Muhammad Sana Ullah Sahar)

Abstract:

Peripheral nerve injuries are relatively common and can be caused by a variety of traumatic events such as motor vehicle accidents. They can lead to long-term disability, pain, and financial burden, and contribute to poor quality of life. In this review, we systematically analyze the contemporary literature on peripheral nerve gap management using nerve prostheses in conjunction with physical therapeutic agents. The use of nerve prostheses to assist nerve regeneration across large gaps (> 30 mm) has revolutionized neural surgery. The materials used for nerve prostheses have been greatly refined, making them suitable for repairing large nerve gaps. However, research on peripheral nerve gap management using nerve prostheses reports inconsistent functional outcomes, especially when prostheses are integrated with physical therapeutic agents, and thus warrants careful investigation. This review explores the effectiveness of nerve prostheses for bridging large nerve gaps and then addresses their use in combination with physical therapeutic agents.

Key words: nerve repair, nerve conduits, nerve prosthesis, physical therapeutic agents, electric stimulation, nerve gap, axonal growth, nerve regeneration