中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (7): 1213-1214.doi: 10.4103/1673-5374.251303

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

LHX1 - POA衍生的中间神经元发育中的多功能调节因子

  

  • 出版日期:2019-07-15 发布日期:2019-07-15

LHX1–a multifunctional regulator in preoptic area-derived interneuron development

Judit Symmank 1, Geraldine Zimmer-Bensch 2   

  1. 1Polyclinic for Orthodontics, University Hospital Jena, Jena, Germany;
    2Department of Functional Epigenetics in the Animal Model, Institute for Biology II, RWTH Aachen University, Aachen, Germany
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Geraldine Zimmer-Bensch, PhD, zimmer@bio2.rwth-aachen.de.

摘要:

orcid: 0000-0001-9347-0172 (Judit Symmank)
           0000-0002-8894-8079 (Geraldine Zimmer-Bensch)

Abstract:

In the cerebral cortex, local inhibition is achieved by different types of gamma-aminobutyric (GABA)-expressing interneurons, representing essential key players of cortical information processing. Their development has to be highly orchestrated to ensure proper numbers and subtype composition in the adult cortex and defects in interneuron development contribute to the pathophysiology of psychiatric diseases. Different from cortical projection neurons, inhibitory interneurons have their origin in proliferative zones in the basal telencephalon from where they have to migrate over long distances up to the cortex. During this migratory process, post-mitotic interneurons have to continuously adopt their morphology and directionality following guidance cues that are expressed in spatiotemporal-specific manner (Zimmer-Bensch, 2018). Detection and integration of environmental signals are achieved by receptor and intracellular signaling proteins that are expressed in a subset-specific manner. This mediates the differential responses of interneuron subtypes to certain guidance factors and provides an explanation for the different migratory streams that appear to correlate with interneuron identity.