中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1367-1368.doi: 10.4103/1673-5374.253515

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

Rac GTPases:神经元发育中的特定结构域功能

  

  • 出版日期:2019-08-15 发布日期:2019-08-15

Rac GTPases: domain-specific functions in neuronal development

Steffen Nørgaard, Roger Pocock   

  1. Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Roger Pocock, PhD, roger.pocock@monash.edu.
  • Supported by:

    This work was supported by a grant from an NHMRC Project Grant (GNT1105374), NHMRC Senior Research Fellowship (GNT1137645), and a Victorian Endowment for Science, Knowledge and Innovation Fellowship (VIF23) (to RP).

摘要:

orcid: 0000-0002-5515-3608 (Roger Pocock)

Abstract:

Understanding fundamental mechanisms governing axon outgrowth and guidance can inform the development of therapeutic strategies to restore neuronal function damaged though injury or disease. Axons navigate the extracellular environment by responding to guidance cues that bind to cell surface receptors to relay information intracellularly via Rho GTPase family members, including the Rac GTPases. Rac GTPases act as master switches to regulate diverse signalling pathways to control the actin cytoskeleton-a major driver of axon outgrowth. However, scant evidence exists concerning how different domains within Rac GTPases regulate specific neurodevelopmental events, such as axon outgrowth and guidance.