中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1374-1375.doi: 10.4103/1673-5374.253516

• 观点:周围神经损伤修复保护与再生 • 上一篇    下一篇

可溶型神经调节蛋白1分子:通过抑制髓鞘形成基因促进周围神经再生

  

  • 出版日期:2019-08-15 发布日期:2019-08-15

Soluble Neuregulin1 (WRG1): a factor promoting peripheral nerve regeneration by affecting Schwann cell activity immediately after injury

Marwa El Soury, Giovanna Gambarotta   

  1. Department of Clinical and Biological Sciences, University of Torino, Torino , Italyal Model, Institute for Biology II, RWTH Aachen University, Aachen, Germany
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Giovanna Gambarotta, PhD, giovanna.gambarotta@unito.it.

摘要:

orcid: 0000-0002-8380-5925 (Giovanna Gambarotta)

Abstract:

Neuregulin-1 (NRG1) is a well known growth factor playing contradictory roles in myelination depending on the existing isoform. Transmembrane NRG1 acts as a promyelinating factor, while the soluble isoform inhibits myelination. In this perspective, we would like to emphasize this conflicting role played by NRG1 isoforms regarding their roles in myelination, remyelination and the entire process of peripheral nerve regeneration.