中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1378-1379.doi: 10.4103/1673-5374.253517

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

肿瘤坏死因子α转换酶是脑损伤再生的关键分子

  

  • 出版日期:2019-08-15 发布日期:2019-08-15

ADAM17/TACE: a key molecule in brain injury regeneration

Samuel Domínguez-García, Carmen Castro, Noelia Geribaldi-Doldán   

  1. PÁrea de Fisiología, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain; Instituto de Investigación e Innovación Biomedica de Cádiz (INIBICA), Universidad de Cadiz, Cádiz, Spain
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Carmen Castro, PhD, carmen.castro@uca.es; Noelia Geribaldi-Doldán, PhD, noelia.geribaldi@uca.es.
  • Supported by:

    This work was supported by the Spanish Consejería de Innovación, Ciencia y Empleo, Junta de Andalucía (P10CTS6639); Ministerio de Econmía y Competitividad (BFU 2015-6852-R, MINECO/FEDER) (both to CC)

摘要:

orcid: 0000-0002-6802-0572 (Carmen Castro)
           0000-0003-2149-9050 (Noelia Geribaldi-Doldán)

Abstract:

It has been many years since “the tumor necrosis factor-α-converting enzyme”, also known as ADAM17/TACE, was described as “the enzyme that does it all” because of its role in neurodegenerative diseases and in several physiological processes including proteolysis, adhesion, intracellular signaling, migration and proliferation. ADAM17/TACE is an integral membrane protein that belongs to the disintegrin and metalloprotease (ADAM)family. Several years ago, Romero-Grimaldi et al. discovered that ADAM17 was involved in the glial/neuronal fate decision of neural progenitor cells (NPCs) in vitro, and this was mediated at least in part, by its capacity to facilitate the release of the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha (TGFα), thus regulating EGFR activation. EGFR, also referred to as ErbB1, belongs to a family of transmembrane receptors, which activate intracellular signaling cascades leading to the phosphorylation of mitogen-activated protein kinase-extracellular signal-regulated kinase or phosphoinositide 3-kinase/protein kinase B. and regulate cell cycle through cyclin expression.