中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1372-1373.doi: 10.4103/1673-5374.253518

• 观点:退行性病与再生 • 上一篇    下一篇

转化观点:肉桂是否适合认知障碍和阿尔茨海默病伴有脑外伤?

  

  • 出版日期:2019-08-15 发布日期:2019-08-15

Translational perspective: is cinnamon a suitable agent for cognitive impairment and Alzheimer’s disease associated with brain trauma?

Burak Yulug, Seyda Cankaya   

  1. Department of Neurology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Burak Yulug, MD, burakyulug@gmail.com.

摘要:

orcid: 0000-0002-9704-6173 (Burak Yulug)

Abstract:

Cinnamon, is an exotic spice and a major constituent of our food which is commonly used in different areas of the world for the treatment of various diseases. Besides its anti-inflammatory, anti-diabetic and anti-cancer properties, cinnamon also exerts strong brain protective and pro-cognitive effects in various models of neurodegeneration. Traumatic brain injury (TBI) is characterized with significant vascular, neuronal and axonal damage that is associated with critical oxidative injury and neuroinflammation. Clinical studies have already conferred that pre and post-injury systemic inflammation could modify the subsequent prognosis of brain injury. Moreover, many pharmacological agents were failed to show a clinical neuroprotective effect after TBI suggesting that there is an emergency need for novel brain protective therapeutic strategies to improve the clinical outcomes. However, although there are increasing promising experimental data, many clinical trials were failed to change the clinical endpoint after TBI. Additionally, studies have already indicated that drug-drug interactions play an essential role in the development of pharmacotoxic side effects. Taken together, these findings might further indicate that a single agent which is acting on multiple cell death pathways may exert a higher neuroprotective activity. Here, cinnamon might be a novel clinical candidate agent for TBI with its multifaceted neuroprotective and procognitive effects, and its superior safety profile. Interestingly, it has been recently revealed that brain trauma has been not only associated with cognitive impairment but also increase the risk of the development of Alzheimer’s disease.