中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1376-1377.doi: 10.4103/1673-5374.253519

• 观点:退行性病与再生 • 上一篇    下一篇

癫痫- 阿尔茨海默病关系的不利作用

  

  • 出版日期:2019-08-15 发布日期:2019-08-15

Detrimental and synergistic role of epilepsy-Alzheimer’s disease risk factors

Mikhail A. Filippov 1, Vasily V. Vorobyov 2   

  1. 1International Medical Cluster, Skolkovo, Moscow Region, Russia;
    2Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Vasily V. Vorobyov, PhD, vorobyovv2@gmail.com.

摘要:

orcid:0000-0002-7716-2580 (Vasily V. Vorobyov)

Abstract:

Identification of individuals at risk for developing Alzheimer’s disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity’s peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular. In this perspective, the roles of various genes linked to epileptogenic mechanisms and the risk of AD development are analyzed. We propose that genotyping of apolipoprotein E (APOE) alleles combined with recording of electroencephalogram (EEG) can identify the early-onset AD that will allow highlighting a cohort of individuals at the risk of AD patients.