中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1470-1472.doi: 10.4103/1673-5374.253533

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小脑梗死患者共济失调恢复过程中皮质脑桥小脑束和齿状红核丘脑束损伤的减轻:弥散张量纤维束成像证据

  

  • 出版日期:2019-08-15 发布日期:2019-08-15
  • 基金资助:

    由Bumsuk学术研究基金提供支持

Improvement of ataxia in a patient with cerebellar infarction by recovery of injured cortico-ponto-cerebellar tract and dentato-rubro-thalamic tract: a diffusion tensor tractography study

Sung Ho Jang 1, Hyeok Gyu Kwon 2   

  1. 1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    2Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi, Republic of Korea
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Hyeok Gyu Kwon, PhD, khg0715@hanmail.net.
  • Supported by:
    This study was supported by Bumsuk Academic Research Fund in 2017 (to HGK). The funding body played no role in the study conception design, in the collection, analysis and inter pretation of data, in the preparation and writing of the report, and in the decision to submit the article for publication.
     

摘要:

皮质脑桥小脑束(CPCT)和齿状红核丘脑束(DRTT)的损伤通常伴随各种脑病理的共济失调。此次研究使用弥散张量纤维束成像(DTT)来显示1例小脑梗死患者损伤皮质脑桥小脑束和齿状红核丘脑束的恢复。
病例为52岁的右侧小脑梗死男性患者,其已接受保守治疗,临床表现为双手轻度运动无力和意向性震颤,以及发病后的躯干性共济失调。发病后1个月开始康复干预,此时DTT检查显示大脑双侧半球的皮质脑桥小脑束较细,未发现齿状红核丘脑束重建。病后3和14个月运动功能明显改善,DTT检查显示大脑双侧半球皮质脑桥小脑束厚度增粗,右侧齿状红核丘脑束重建。DTT检查证实了小脑梗死患者共济失调恢复过程中皮质脑桥小脑束和齿状红核丘脑束损伤的减轻。

orcid: 0000-0002-6654-302X (Hyeok Gyu Kwon)

Abstract:

Coordinated movement is generated by communication between the cerebrum and cerebellum via the cerebellar peduncles (CPs). The CPs are classified into three types (superior, middle, and inferior), and each includes a variety of neural tracts. Among those tracts, the cortico-ponto-cerebellar tract (CPCT), a middle CP, is involved in motor planning and initiation of movement, while the dentato-rubro-thalamic tract (DRTT), a superior CP, is involved in motor coordination, movement timing, verbal fluency, and working memory . Injuries of these two neural tracts in various brain pathologies are commonly accompanied by ataxia. In particular, cerebellar infarction results in inevitable injuries of the CPCT and the DRTT, and over 50% of patients with cerebellar infarction experience ataxia.