中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (10): 1707-1708.doi: 10.4103/1673-5374.257519

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

HIV感染期间星形胶质细胞和淋巴细胞死亡的机制是否相似?

  

  • 出版日期:2019-10-15 发布日期:2019-10-15

Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?

Diego S. Ojeda 1, Andreas Till 2, Jorge Quarleri 1   

  1. 1Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires-CONICET, Argentina;
    2 Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn, Bonn, Germany
  • Online:2019-10-15 Published:2019-10-15
  • Contact: Jorge Quarleri, PhD, quarleri@fmed.uba.ar
  • Supported by:

    This work was supported by the Argentinean National Agency of Scientific and echnological Promotion (PICT 2015-1921), by the University of Buenos Aires (20020110100034); by the German Federal Ministry of Education and Research (BMBF) and the German Research Foundation (DFG).

摘要:

orcid: 0000-0001-5110-8773 (Jorge Quarleri)

Abstract:

Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associated with euroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled.