中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (11): 1870-1879.doi: 10.4103/1673-5374.259603

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

糖尿病神经病学研究:从小鼠模型到治疗目标

  

  • 出版日期:2019-11-15 发布日期:2019-11-15

Diabetic neuropathy research: from mouse models to targets for treatment

Vuong M. Pham 1, 2 , Shinji Matsumura 1 , Tayo Katano 1 , Nobuo Funatsu 1 , Seiji Ito 1, 3   

  1. 1 Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan
    2 Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore
    3 Department of Anesthesiology, Osaka Medical College, Takatsuki, Osaka, Japan
  • Online:2019-11-15 Published:2019-11-15
  • Contact: Seiji Ito, MD, PhD, s-ito@osaka-med.ac.jp.

摘要:

orcid: 0000-0002-0942-1624(Seiji Ito)

Abstract:

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

Key words: brain derived neurotrophic factor, diabetes, extrinsic factors, nerve growth factor, nerve regeneration, neurotrophic factors, non-obese type 2 diabetes, phosphatase and tensin homolog, stem cell, streptozotocin