中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (11): 1907-1908.doi: 10.4103/1673-5374.259607

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

肌肉LIM蛋白在神经系统中的作用

  

  • 出版日期:2019-11-15 发布日期:2019-11-15

The role of muscle LIM protein in the nervous system

Daniel Terheyden-Keighley, Dietmar Fischer   

  1. Department of Cell Physiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Germany
  • Online:2019-11-15 Published:2019-11-15
  • Contact: Dietmar Fischer, PhD, dietmar.fischer@rub.de.
  • Supported by:

    This work was supported by the German Research Foundation (FI 867/12, to DF).

摘要:

orcid: 0000-0002-1816-3014 (Dietmar Fischer)

Abstract:

Unlike the peripheral nervous system (PNS), the central nervous system (CNS) has a low intrinsic regenerative capacity and has mechanisms that actively suppress axon regrowth, for example, glial scarring and myelin inhibition. Even in the PNS, which has the principle ability to regenerate injured axons, functional recovery remains limited, particularly in cases where the nerve target has become unreceptive to re-innervation over time due to an insufficient axonal growth rate . Progress towards robust neuroregenerative therapies depends upon an understanding of the relevant signaling and cytoskeletal proteins that drive and control axon extension. Muscle LIM  protein (MLP), also known as cysteine and glycine-rich protein 3, was recently discovered to be one such protein that is expressed in regenerating rat neurons and whose overexpression can promote the axon regeneration of adult central, and peripheral neurons of different species.