中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2063-2066.doi: 10.4103/1673-5374.262569

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

转向髓鞘逆转

  

  • 出版日期:2019-12-15 发布日期:2019-12-15

Turning to myelin turnover

Tobias J. Buscham , Maria A. Eichel , Sophie B. Siems , Hauke B. Werner   

  1. Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Hauke B. Werner, Hauke@em.mpg.de.
  • Supported by:

     This work was supported by the Deutsche Forschungsgemeinschaft (DFG, WE2720/2-2 and WE2720/4-1, both to HBW).

摘要:

orcid: 0000-0002-7710-5738(Hauke B. Werner)

Abstract:

Neural plasticity in the adult central nervous system involves the adaptation of myelination, including the formation of novel myelin sheaths by adult-born oligodendrocytes. Yet, mature oligodendrocytes slowly but constantly turn over their pre-existing myelin sheaths, thereby establishing an equilibrium of replenishment and degradation that may also be subject to adaptation with consequences for nerve conduction velocityIn this short review we highlight selected approaches to the normal turnover of adult myelin in vivo, from injecting radioactive precursors of myelin constituents in the 1960s to current strategies involving isotope labeling and tamoxifen-induced gene targeting.

Key words: oligodendrocyte, myelin plasticity and turnover, degradation, tamoxifen, metabolic labeling, isotope labeling, neural plasticity, myelinoid bodies, central nervous system